All Rights Reserved. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Melphalan (Wikipedia entry) Contents[show] Mechanism Gomez-Bougie et al. The vaccine may not work as well and may not fully protect you from disease. Leukemia & Lymphoma: Vol. Other drugs may affect melphalan, including prescription and over-the-counter medicines, vitamins, and herbal products. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine. Melphalan may cause other side effects. You should not plan to have children while receiving chemotherapy or for a while after treatments. It is also sometimes used to treat amyloidosis (a disease in which abnormal proteins build up in tissues and organs in the body). Ask your pharmacist any questions you have about refilling your prescription. AHFSÂ® Patient Medication Informationâ¢. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Tell your doctor at once if you develop signs of infection. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). However, it is important to use birth control to prevent pregnancy because melphalan can harm an unborn baby. Biotech Park, Kolthur, Shameerpet, Hyderabad-500078, Telangana, India. (2005) report that melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex. Melphalan drug interactions (in more detail). Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin redness; blurred vision, feeling light-headed; fast heartbeats; trouble breathing; swelling of your face, lips, tongue, or throat. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your doctor about the risks of using this medication for your condition. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Take melphalan at around the same time every day. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Tell your doctor if you now have or have ever had: an infection or weak immune system (caused by disease or by using certain medicine); Using melphalan may increase your risk of developing other cancers, such as leukemia. Store melphalan tablets in the refrigerator and protect them from light. Talk to your doctor about how you are feeling during your treatment. Your doctor will determine how long to treat you with this medicine. You may report side effects to FDA at 1-800-FDA-1088. Generic Name: melphalan (oral/injection) (MEL fa lan)Brand Name: Alkeran, Alkeran I.V., Evomela, Medically reviewed by Drugs.com on May 14, 2020 – Written by Cerner Multum. While using melphalan, you may get infections more easily, even serious or fatal infections. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Melphalan oral is usually taken daily and your doctor may occasionally ask you to stop taking it for a short time. low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. Your doctor will probably tell you not to take melphalan. This is not a complete list of side effects and others may occur. It works by stopping or slowing the growth of cancer cells in your body. do not have any vaccinations without talking to your doctor. You may not get the full benefit of this medicine if you stop using it too soon. Unique Biotech Limited - Melphalan Tablets Ip, Honey & Pantoprazole Domeperidone Manufacturer from Hyderabad, Telangana, India Melphalan oral is usually taken daily and your doctor may occasionally ask you to stop taking it for a short time. In-vivo studies Souliotis et al. Select one or more newsletters to continue. Information is also available online at https://www.poisonhelp.org/help. 2, Phase-2, S.P. Melphalan injection is given as an infusion through a central intravenous (IV) line placed into a large vein. Your cancer treatments may be delayed based on the results of your blood tests. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What special precautions should I follow? The American Society of Health-System PharmacistsÂ®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine. Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan may also be used for purposes not listed in this medication guide. This medicine may affect fertility (ability to have children) in both men and women. 633-634. These and others are described below. It may take several months before your body responds to melphalan. URL of this page: https://medlineplus.gov/druginfo/meds/a682220.html. What should I know about storage and disposal of this medication? Be sure to mention any of the following: carmustine (BICNU, BCNU), cimetidine (Tagamet), cisplatin (Platinol AQ), cyclosporine (Sandimmune, Gengraf, Neoral), or interferon alfa (Intron A, Infergen, Alferon N). Version: 6.01. Follow your doctor's dosing instructions very carefully. 4, pp. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan may increase the risk that you will develop other cancers. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. For best results, keep using melphalan as directed. You may be given another medication to help prevent nausea. The molecular formula is C13H18Cl2N2O2 and the molecular weight is 305.20. Therefore, it is strongly recommended that patients chew on ice some 20 minutes prior to receiving treatment, during the infusion, and for several minutes afterwards. You should not breastfeed while using melphalan. Velcade, Gemzar, Adriamycin, Doxil, Ninlaro, Avastin, cyclophosphamide, Empliciti, Pomalyst, Revlimid. As a palliative treatment for ovarian cancer: Melphalan oral is usually taken for 5 days in a row every 4 to 5 weeks. Your blood will need to be tested often. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Keep using this medicine and tell your doctor if you have severe nausea, vomiting, or diarrhea. (2005). Â© Copyright, 2020. GST 36AAACU4379H1Z3, Unique Biotech LimitedPlot No. Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed).
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